Puncture (biopsy) of the thyroid gland

Thyroid diseases are a group of complex pathologies that occur when the endocrine system malfunctions and the thyroid gland stops producing the hormones needed by the body.

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General information about the procedure

Fine-needle aspiration biopsy (FNAB) is a simple and accurate way to diagnose thyroid pathologies. The procedure involves the doctor using a thin needle to remove a small amount of tissue from the desired location under ultrasound guidance.

Why is FNAB performed? If an examination reveals a lump of unknown origin within the thyroid gland, it is important to determine the nature of the lesion. The procedure helps differentiate a benign tumor from a malignant one. The tissue sample allows for an accurate diagnosis and the appropriate treatment. The results of the procedure also allow for monitoring the patient's condition over time.

FNAB is convenient because it is virtually painless, quick, and provides an accurate picture of the thyroid gland's condition. The thin needle causes minimal tissue trauma, the procedure takes just minutes, and recovery is quick and unnoticeable. Most biopsies do not require anesthesia. This type of examination can be performed at many clinics, for example, at the K+31 Family Multidisciplinary Center (Moscow).

General information about the procedure
Indications for thyroid puncture

Indications for thyroid puncture

There are many situations where it is necessary to conduct this examination under ultrasound guidance. Here are the main ones:

  • Noticeable enlargement of the thyroid gland
  • Rapid growth of glandular tissue
  • Changes in hormonal levels
  • The need to examine tissue structure
  • Changes in the shape of the thyroid gland due to abnormalities in organ formation
  • Nodes detected by palpation or ultrasound (one large one over a centimeter, a small one less than a centimeter in the presence of unfavorable factors, or several small formations)
  • Suspected autoimmune pathology
  • Symptoms of decreased or increased thyroid activity

There are no strict contraindications to performing an aspiration biopsy, but sometimes the risks of possible consequences are so high that the doctor reschedules the puncture for another time.

Contraindications to the procedure

Contraindications to the procedure

Ultrasound-guided aspiration biopsy has a number of limitations, including the following:

  • Blood clotting problems
  • Skin inflammation at the planned puncture site
  • Active infections or inflammation
  • Patient refusal for any reason

These contraindications to this minimally invasive medical procedure may be temporary. The doctor may collect biopsy material from the thyroid gland if these conditions no longer apply.

Types of thyroid diseases

The most common pathologies of the endocrine system include chronic functional and morphological diseases:

  • Hypo-(hyper-)thyroidism (impaired production of thyroid hormones)
  • Secondary hyperthyroidism (pituitary gland diseases)
  • Autoimmune thyroiditis (inflammation of the thyroid gland)
  • Diffuse nodular goiter (iodine deficiency in the body)
  • Thyrotoxicosis (excess of thyroid hormones in the body)
  • Graves' disease (critical excess of T3-T4 hormones)
  • Malignant tumors of the thyroid gland

There are two main causes of endocrine Pathologies:

  • Loss of the thyroid gland's ability to produce essential hormones (impaired iodine metabolism due to poor absorption, abnormal protein transporters)
  • Disruption of autoimmune processes (production of antibodies hostile to the thyroid)

Endocrine pathologies are usually caused by genetic predisposition, chronic mental stress, a critical decrease in immune defense, complex infections, chronic pathologies or traumatic brain injuries, age-related changes in the body, severe exposure to unfavorable environmental or radiation conditions, an unbalanced diet and a deficiency of vitamins and minerals, and the use of strong medications.

Features

  • The incidence of thyroid diseases has been rapidly increasing in recent years (second only to diabetes mellitus)
  • Nodular or endemic goiter has been diagnosed in more than 650 million people worldwide
  • 1.5 billion people worldwide suffer from iodine deficiency disorders, and the number of patients is growing by 5% annually
  • In some regions of the world, treatment for thyroid diseases is required for 95% of the population
  • Thyroid pathologies are becoming "younger" every year and cause many cardiovascular and mental illnesses with a wide range of symptoms
  • Thyroid diseases (decreased hormone levels) more often affect women (19/1)

At the initial stage, most thyroid diseases show weak symptoms and "mask" as other diseases. If you do not seek medical attention If an endocrinologist fails to conduct a thorough, timely diagnosis, serious complications that pose a threat to life may arise.

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Symptoms

Thyroid disease symptoms vary widely, but most are related to the body's inability to produce the required amount of thyroid hormones T3-T4.

Thyroid disorders result in decreased production of T3-T4 hormones (hypothyroidism) or an excess of them (hyperthyroidism). In the first case, metabolic processes are slowed down, and in the second, they accelerate and create a burden on the internal organs.

If hormones are not produced in sufficient quantities (autoimmune thyroiditis, hypothyroidism), the patient experiences:

  • Weakness, fatigue, chills, and constant drowsiness
  • Mood swings, depression, deterioration of mental activity
  • Slowing of the heart and a drop in blood pressure
  • Swelling of the face and extremities
  • Weight gain
  • Irregularities in the menstrual cycle in women
  • Dry skin, hair, and nails

Hyperthyroidism (excess of T3-T4 hormones), on the contrary, causes:

  • Increased Muscle motility and motor activity
  • Increased mental activity
  • Anxiety and irritability, sleep disturbances
  • Increased blood pressure and heart rate, arrhythmia
  • Increased body temperature and sweating
  • Increased metabolism, increased appetite, rapid weight loss
  • "Bulging eyes" effect (exophthalmos)

Diffuse nodular goiter manifests symptoms in the late stages (hoarseness, visible cervical nodes, difficulty breathing/swallowing). In the early stages, the disease can only be detected by ultrasound.

Malignant tumors are also difficult to diagnose in the early stages. In the later stages, they are accompanied by weakness, weight loss, pain, and inflammation of the internal organs (cancer intoxication).

General information

Preparing for a Thyroid Puncture

No special preparation is required before the biopsy. The biopsy itself is similar to a regular injection and takes a few minutes at most.

The correct procedure:

  • Schedule. You can easily schedule an appointment online at the K+31 Family Center website or by calling.
  • Consultation. During the first visit, the doctor will conduct an examination, ask questions about your health, and schedule the biopsy.
  • Puncture. It is performed under strict ultrasound guidance, ensuring the accuracy of all procedures.

Please bring your passport, a referral from your family doctor (if applicable), and previous doctor's reports or ultrasound images (if available). Taking care of your health starts with simple steps, and the first of these is timely diagnosis.

Ultrasound-guided thyroid puncture

Diagnosis

Diagnosing endocrine diseases is a complex process that must begin early. Endocrinological diagnostics include:

  • Examination of the patient's appearance (eyes, hair, skin)
  • Observations of behavioral functions (speech, behavior)
  • Physical examinations and medical history
  • Immunodeficiency and enzyme immunoassay of blood and plasma (subclinical test for hormones T3, T4, TSH)
  • Determination of antibody levels in the blood
  • Ultrasound diagnostics of the gland size/volume
  • Scintigraphy (determines glandular structural abnormalities) and thermography
  • Doppler mapping (study of blood flow within the thyroid gland)
  • Cytological examinations
  • Fine-needle aspiration biopsy with ultrasound (FNAB) in diagnostics Malignant tumors
  • Isotope diagnostics (iodine or technetium)
  • Ultrasound examination of internal organs for effects on thyroid function
Ultrasound diagnosis of a thyroid nodule

How is a thyroid biopsy performed?

The procedure is similar to a standard subcutaneous injection. It is virtually painless and minimally invasive, and is performed right in the clinic without any prior preparation. No dietary changes, medications, or blood donations are required before the aspiration biopsy.

The procedure is performed without anesthesia, as the use of anesthetic medications can distort the ultrasound image and affect the accuracy of the tissue analysis. The patient lies on their back, and an experienced physician makes a small puncture with a syringe holding approximately 5-10 milliliters. All needle movements are controlled by a modern ultrasound machine, allowing for precise placement of the needle in the desired area of ​​the gland.

Typically, two or three punctures are made in different parts of the nodule to collect a sufficient amount of tissue and minimize the risk of errors. The entire procedure rarely lasts more than fifteen minutes and is well tolerated by most people. The patient is discharged immediately after the biopsy. The puncture site is covered with a special bandage, which can be removed after a couple of hours. Thyroid punctures can be performed in Moscow at the K+31 clinic.

Thyroid aspiration biopsy - procedure steps

Treatment and Results

Treatment of thyroid diseases depends on the diagnostic results and the hormonal status determined by the patient. Typically, in the early and middle stages of the disease, conservative treatment (hormonal therapy and chemotherapy) is prescribed, aimed at suppressing or stimulating the thyroid's production of T3 and T4 hormones.

Drug therapy may involve lifelong use of hormonal stimulants or antithyroid drugs (which inhibit hormone production). These treatments can have side effects and lead to drug addiction or thyroid tissue atrophy. Therefore, in recent years, medicine has been actively using safe herbal preparations with high iodine content and active plant components.

In cases of pathological nodules and tumors (toxic goiter, etc.) causing difficulty swallowing and breathing, surgical resection of the nodule or portion of the thyroid gland, as well as thyroidectomy, is used. After surgery, however, the patient requires a rehabilitation period and lifelong hormonal therapy. The use of modern minimally invasive surgical techniques significantly reduces postoperative stress and shortens the rehabilitation period.

Results and Interpretation

A tissue sample taken by ultrasound-guided biopsy is sent to a lab, where it is analyzed for about a week. Based on the results, doctors can determine the nature of the nodule found. The analysis results are recorded according to a special Bethesda score, which has six possible values:

  • The information obtained is not clear enough. This happens if there were errors in sample collection.
  • Benign thyroid nodules detected.
  • Difficulty interpreting the results. In this case, the doctor orders additional testing of the same area.
  • The sample contains elements of follicular neoplasia, which indicates the possible beginning of the transformation of healthy cells into pathological ones.
  • There is reason to suspect thyroid cancer.
  • Oncology has been diagnosed.

The biopsy result is added to the patient's medical record.

Prevention

Prevention of thyroid disease involves:

  • Introducing iodized salt into the diet, as well as milk, bread, bran with a high iodine content, greens, seaweed, fish and seafood, legumes, nuts, persimmons, kiwi, and chokeberries.
  • Taking herbal preparations and medicinal herbs with a high content of iodine, cobalt, manganese, and protein.
  • Taking immune-boosting medications.
  • Analgesic, sedative, and tonic herbal treatments.

After the procedure: rehabilitation and care

After the ultrasound-guided biopsy, the patient can safely return to their normal activities. The doctor may allow the bandage to be removed from the puncture site after one to two hours. It is then important to limit physical activity and avoid hot baths for at least 24 hours.

Slight swelling or edema around the puncture site may be observed for some time after the procedure, but this discomfort will subside fairly quickly. If this does not occur, follow-up with a doctor is required.

After a thyroid puncture: recovery and care

Complications and Risks

After the puncture, there is a small risk of the following:

  • Minor bleeding
  • Breach of adjacent tissues or organs
  • Infection
  • Hematoma

The risk of complications is negligible if you undergo the puncture by an experienced physician in a modern clinic. The puncture is performed strictly under ultrasound guidance, ensuring precise placement of the needle in the desired area. If complications occur, you should consult a medical center.

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