Anti-aging therapy – medicine for healthy longevity

Anti-aging therapy in the modern sense is not beauty injections or supplements "for youth." It is evidence-based medicine aimed at managing biological age: eliminating hormonal deficiencies, correcting metabolic disorders, and reducing the risk of age-related diseases.

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Evidence-based medicine and a rigorously scientific approach
Qualified doctors with extensive experience
Innovative methods with proven effectiveness

K+31 on Lobachevskogo

st. Lobachevskogo, 42/4

Prospekt Vernadskogo
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K+31 Petrovskie Vorota

1st Kolobovsky pereulok, 4

Tsvetnoy Boulevard / Trubnaya
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K+31 West

Orshanskaya, 16/2; Ak. Pavlova, 22

Molodyozhnaya
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What is biological age and why is it more important than passport age?

In 2026, healthy longevity medicine was enshrined in the Russian Federation State Guarantees Program for the first time, and in April 2026, the Ministry of Health officially introduced the position of "healthy longevity medicine doctor." Russia has joined the global Longevity trend, and K+31 offers its best practices in a private clinic format.

Passport age indicates how many years have passed since birth. Biological age reflects the actual state of cells, the hormonal system, vascular system, and metabolism—and it determines well-being, performance, and long-term risks.

Two people with the same passport age can have biological ages that differ by 10–15 years. The goal of anti-aging therapy is to close this gap: slow the process of premature aging, restore hormonal balance, and eliminate the deficiencies that underlie most age-related complaints.

Key markers of biological age, assessed in K+31:

  • Metabolic indicators: glucose, insulin, HOMA-IR, lipid profile
  • Hormonal profile (sex hormones, cortisol, thyroid hormones, IGF-1)
  • Inflammation indicators: highly sensitive CRP, interleukins
  • Nutrient status: vitamin D, B12, ferritin, magnesium
  • Adrenal function: DHEA-S (a marker of the body's "hormonal reserve")
  • Body composition: muscle mass, fat percentage, Visceral fat (bioimpedance analysis or DEXA)
What is biological age and why is it more important than passport age?

Anti-aging therapy options

Menopausal hormone therapy (MHT)

The most studied and effective anti-aging component for women during peri- and postmenopause. According to the updated clinical guidelines of the Russian Ministry of Health (2025), HRT is the method of choice for the correction of climacteric disorders.

Symptoms for which HRT is indicated:

  • Hot flashes, night sweats
  • Sleep disturbances
  • Vaginal dryness, sexual dysfunction
  • Decreased libido
  • Mood swings, anxiety
  • Decreased concentration, "brain fog"

Long-term effects of HRT (if started in a timely manner):

  • Prevention of osteoporosis and reduction of fracture risk
  • Reduction of cardiometabolic risks when starting HRT in the "therapeutic window" (up to 60 years or (within 10 years after menopause)
  • Reduced risk of type 2 diabetes
  • Maintaining muscle and cognitive function

Principles of MHT administration in K+31:

Drug selection, dose, and route of administration are strictly individualized. Modern regimens—transdermal estrogens + micronized progesterone—have the best safety profile. Mandatory comprehensive examination before prescribing: mammography, gynecological examination, tests, assessment of personal and family oncological history, Russian eligibility criteria for cardiovascular and metabolic pathology.

New in 2025: The Russian Ministry of Health has removed from its recommendations the clause on the undesirability of MHT in the absence of "clear indications" — refocusing on active, individualized use.

Correction of Androgen Deficiency in Women

After menopause, testosterone levels decrease by 2-4 times. Symptoms include decreased libido, chronic fatigue, loss of muscle mass, and decreased motivation. Correction with low doses of testosterone is an option for patients with appropriate symptoms and an already prescribed baseline MHT.

Menopausal hormone therapy (MHT)

Anti-aging Therapy Options for Men

Testosterone Replacement Therapy (TRT)

Testosterone levels begin to decline around age 35–40, at a rate of about 1–2% per year. Clinically significant deficiency (hypogonadism)—total testosterone levels < 12 nmol/L combined with symptoms.

Symptoms of androgen deficiency:

  • Chronic fatigue, decreased performance
  • Decreased libido, erectile dysfunction
  • Increase in visceral fat
  • Decreased muscle mass and strength
  • Mood swings, irritability, depression
  • Memory and concentration impairment

According to the consensus of five international associations (2025): hypogonadism should be considered a key marker of a man's overall health. TRT provides a moderate but statistically significant improvement in sexual function, bone mineral density, and insulin sensitivity, without significantly increasing cardiovascular risk in appropriately selected patients.

Drug forms (individual selection):

  • Transdermal gels (daily) - physiological profile
  • Long-acting injections (every 10-14 weeks) - ease of use
  • Oral forms - limited use

Mandatory monitoring during TRT: testosterone levels, PSA, hematocrit, lipid profile, liver function.

Anti-aging therapy options for men

IGF-1 and Somatotropic Function

With age, growth hormone and IGF-1 levels decline, which is accompanied by muscle loss, increased adipose tissue, and decreased regenerative capacity. Assessing somatotropic function is a component of a comprehensive anti-aging assessment.

Nutrition and Metabolic Correction

DHEA and "Hormonal Reserve"

Dehydroepiandrosterone (DHEA) is a "precursor" of sex hormones. Its serum level progressively declines beginning at age 30, reaching only 10-20% of youth levels by age 80. DHEA-S is a marker of the body's "hormonal reserve." Correction is considered on an individual basis if there is a significant decrease and corresponding symptoms.

Metabolic Health and Body Composition

Visceral obesity, insulin resistance, and chronic inflammation are the main drivers of accelerated aging. A K+31 endocrinologist evaluates the metabolic profile comprehensively: glucose, insulin, HOMA-IR, HbA1c, body composition (muscle/fat/water), and inflammatory markers. If necessary, modern medications (GLP-1 agonists) are used to correct body weight and metabolism.

IGF-1 and somatotropic function
Manage your youth and energy

Manage your youth and energy


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Frequently Asked Questions (FAQ)

At what age should anti-aging diagnostics begin?

The optimal starting point is 35–40 years of age, when the first changes in hormone levels are still reversible or easily corrected. However, anti-aging testing is relevant at any age.

Is hormone therapy dangerous? Is it true that it causes cancer?

Current data (2024–2025) show that with the correct selection of drugs and route of administration (transdermal estrogen + micronized progesterone in women; adequate doses of testosterone in men), the risks are minimal. Unjustifiably refusing therapy is more dangerous than using it: untreated hormone deficiency is associated with osteoporosis, cardiovascular disease, and dementia.

Will dietary supplements and biohacking without hormones help?

Nutrient support, physical activity, and stress management are important parts of an anti-aging strategy. However, in the case of a true hormonal deficiency, they are no substitute for hormonal correction. Anti-aging at K+31 integrates all approaches, but prioritizes evidence-based medicine.

What is the difference between anti-aging treatments in a clinic and in a beauty center?

At the clinic: diagnosis → laboratory diagnostics → prescription from a licensed physician → registered medications → safety monitoring. At the beauty center: procedures without diagnostics, supplements without testing, no legal or medical liability for the results.

Do I need to make any special preparations for my first visit?

It's a good idea to bring your test results for the last year (if available). During your first visit, your doctor will determine which tests are necessary for you.

Our doctors

Belyaeva Anna Vladimirovna
Experience 22 years
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Belyaeva
Anna Vladimirovna
Endocrinologist
Dzhabrailov Jabrail Abdulazizovich
Experience 25 years
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Dzhabrailov
Jabrail Abdulazizovich
Urologist, andrologist
Yuryeva Anna Evgenievna
Experience 28 years
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Yuryeva
Anna Evgenievna
Gastroenterologist, preventive medicine doctor
Briskman Tatyana Dmitrievna
Experience 5 years
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Briskman
Tatyana Dmitrievna
Endocrinologist, nutritionist
Kanevskaya Svetlana Sergeevna​
Experience 26 years
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Kanevskaya
Svetlana Sergeevna​
Zamestitel Glavnogo Vracha Po Vnutrennim Boleznyam I Meditsine Dolgoletiya, D.m.n., Professor​
All specialists
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Our doctors are laureates of the ProDoctors Award
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Reviews

A very attentive, knowledgeable and pleasant doctor.
26.04.2026
Nataliya T.
I would like to express my deep gratitude to Dr. Dzhabrailov for his professionalism and truly attentive attitude to the patient. For more than 12 years I have been suffering with the disease, I have consulted various specialists, but unfortunately, during all this time no doctor has been able to clearly explain what is really happening to me. The treatment was superficial, the tests were taken formally and, as it has now become obvious, often incorrectly. Dr. Dzhabrailov explained everything in detail, sorted it out, prescribed the correct tests and showed what the diagnosis should actually look like. For the first time in many years, I had an understanding of my situation and confidence that I was moving in the right direction.
26.04.2026
Timur H.
An excellent specialist. It's not the first time I've seen him. Attentive to patients, professional in his field. Yes, and as a man,
21.04.2026
Ivan Zh.
A wonderful specialist. From the first minute, professionalism and confidence were felt. Thanks for the help!
30.03.2026
Dmitriy A.
Anna Evgenievna is a true professional! Thank you so much for your consultation, support, and treatment.
12.01.2026
M. Valentin Sergeevich

About doctor:

Yuryeva Anna Evgenievna

Wonderful doctor, I am very grateful to him.
21.12.2025
T. Alexandra Alexandrovna
Excellent doctor, she examined everything carefully, gave the necessary recommendations, I will come again, thank you
26.11.2025
Ch. Alexandra Mikhailovna
A real doctor. You don't meet people like him very often.
25.11.2025
S. Igor Vyacheslavovich

About doctor:

Yuryeva Anna Evgenievna

The best doctor in his field. I've gone to him several times.
16.11.2025
J. Ivan Ivanovich
Very professional approach to solving my problem. Great doctor.
09.11.2025
M. Alexander Vladimirovich

About doctor:

Yuryeva Anna Evgenievna

Почему К+31?
К + 31 — full-cycle multidisciplinary medical centers, including the possibility of providing medical services of European quality level.
К + 31 — are leading doctors and diagnostics using high-tech equipment from world manufacturers (Karl Storz, Olympus, Siemens, Toshiba, Bausch&Lomb, Technolas, Zeiss, Topcon).
К + 31 — is ethical. The staff of K+31 clinics maintain open relationships with patients and partners. An individual approach to each patient is the basis of our service standards.
К + 31 — is modernity. On call 24/7: call center operators will answer your questions at any time and book you an appointment with doctors. Contact us by phone, through the feedback form on the website and Max.

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Address K+31 Petrovskie Vorota

1st Kolobovsky pereulok, 4

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+7 499 999-31-31

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