Urea norm in biochemical analysis (UREA)

Urea is a substance that plays a huge role in protein metabolism. The main difference of any protein is the presence of a large amount of nitrogen as a chemical element. During metabolism, this nitrogen is released, and ammonia is formed from it - one of the most toxic for the body. Formed on the periphery, it enters the liver, where, under the action of special enzymes, it turns into less toxic urea, which is sent to the kidneys and excreted in the urine.

UREA is a key indicator of the excretory capacity of the kidneys. If their function is impaired, then this compound does not pass the renal filter and is retained in the vascular bed. The norm is 2.5 – 8.3 mmol/l. In middle-aged people, the indicator should not exceed 6.9 – 7.2. A number of laboratories identify different upper limits for men and women: 7.1 and 6.8, respectively.

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Urea norm in biochemical analysis (UREA)

Normal values ​​may vary depending on:

  • Diet (protein-rich foods)
  • Intensity of physical labor;
  • Taking a number of medications (hormone therapy)

Excess may indicate:

  • Renal pathology (acute inflammation and exacerbation of chronic, associated with infection, intoxication, autoimmune diseases)
  • Dysfunction of the urinary system associated with obstruction of the normal outflow of urine (stones, tumors of the ureters, bladder, urethra)
  • Systemic oncological processes (metastases, tumor lesions of the red bone marrow)
  • Severe somatic conditions (cardiac and respiratory failure)

Extensive injuries (especially with muscle compression), burns, frostbite, poisoning, severe infections also lead to an increase in concentration.

It is necessary to take into account that with all the above pathologies, other changes (characteristic symptoms, shifts in accompanying studies) should be present in the clinical picture. Isolated increase is quite rare and requires repeated determination.

A decrease in the level indicates violations of protein and nitrogen metabolism. Sometimes this condition is more dangerous than high numbers. This is associated with liver disease (cirrhosis, hepatosis, hepatitis), which is not able to neutralize ammonia and convert it into less toxic compounds. The toxin accumulates and has a pronounced negative effect.

Low values ​​are observed in exhausted patients.

Blood should be donated when symptoms such as:

  • Edema
  • Back pain
  • Cloudy urine or other impurities
  • Dysuric disorders (frequent, painful urination)
  • Changes in general tests

If a diagnosis has already been established, the doctor himself determines the indications for the study. As a rule, the level of creatinine, bilirubin and total protein is determined in parallel for a comprehensive assessment of the pathological process.

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Ivanova Natalya Vasilevna
Experience 24 years
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Ivanova
Natalya Vasilevna
Head of the Department of Internal Medicine, general practitioner
Zykova Anastasia Sergeevna
Experience 11 years
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Zykova
Anastasia Sergeevna
Doctor rheumatologist, nephrologist
Kulikova Maria Igorevna
Experience 3 years
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Kulikova
Maria Igorevna
Nephrologist
Chervinko Valery Ivanovich
Experience 20 years
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Chervinko
Valery Ivanovich
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Reviews 8

A very attentive doctor who delves into the problem.
13.10.2025
Kh. Tatyana Mikhailovna
The most attentive and erudite doctor who has ever examined me, thank you very much!! I visited this clinic at the beginning of the month, I had stabbing, paroxysmal pain in the joints. The appointment was with Zykova Anastasia Sergeevna. In general, I liked everything, they greeted me warmly. The appointment was held in a friendly atmosphere. Diagnostics were prescribed. As it turned out, I had arthralgia, immediately after the diagnosis was established, a further course of treatment was created. They treated me politely and in a calm atmosphere.
25.08.2025
Anonymously
Very competent and attentive doctor, nephrologist Chervinko Valery Ivanovich
08.08.2025
Anonymously
Anastasia Sergeevna adjusted my therapy taking into account my renal failure, thank you very much for your professionalism and attention! You have helped me a lot and continue to help me, I trust you completely.
04.07.2025
S. Nadezhda Ruvimovna
The most attentive and erudite doctor who has ever examined me, thank you very much!!
04.07.2025
S. Nadezhda Ruvimovna
Anastasia Sergeevna, thank you very much! You are a real expert in your work! Only you approached my problem professionally, competently, and delicately. You know how to listen, draw conclusions, and help. I am very grateful to you!
04.12.2023
Klim Yulia Viktorovna
I visited a rheumatologist-nephrologist Zykova Anastasia Sergeevna. Very caring and systematic doctor. Approaches the problem of the patient comprehensively. I received answers to all my questions. Thanks a lot!
31.10.2022
Danilova Irina Viktorovna
I would like to thank Natalya Vasilievna for the treatment! The singing reception was remembered for the attentive attitude and determination to find out in detail not only my complaints, but also my general condition. I was prescribed several tests, while explaining what why and why. After repeated admission, I already had a treatment program on hand, which, as a result, had an effect. Best regards, Leonid Petrovich.
12.08.2017
Leonid Petrovich
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