Bipolar Affective Disorder

Bipolar affective disorder (the old name is manic-depressive psychosis) is a severe mental illness, the main sign of which is the alternation of manic attacks with bouts of depression. In some cases, both of these conditions can occur simultaneously, forming a mixed manic-depressive psychosis.

Causes of Bipolar Affective Disorder

At the heart of bipolar affective disorder is a metabolic disorder of neurotransmitters and other biologically active substances that regulate the functioning of brain neurons. A direct effect on the biochemical processes in the nervous tissue is exerted by changes in the endocrine system (especially in the thyroid gland and adrenal glands), disturbances in the water-salt balance in the body, circadian rhythms and other factors. However, to date, the specific mechanism and pathological physiology of this process has not been finally disclosed.

It is reliably known that there are risk factors against which the frequency of bipolar affective disorder increases markedly. These factors include:

  • Psychological trauma;
  • Severe somatic diseases (past or ongoing);
  • The postpartum period (postpartum depression) and menopause in women;
  • Melancholy personality type;
  • Postponed neurosis, neurasthenia;
  • Emotional lability;
  • Substance use.

The role of genetics and hereditary factors in the development of manic-depressive psychosis is not questioned. Currently, researchers are doing a lot of work to identify specific genes, changes in which can lead to bipolar affective disorder.

The clinical picture of manic-depressive psychosis

In manic-depressive psychosis, two opposite phases or episodes are distinguished: manic and depressive.

The episode of mania includes three main symptoms: increased mood, motor arousal, and mental arousal. In a manic episode, hyperactivity, loud laughter, talkativeness, active facial expressions and gestures, short sleep (not more than 4-5 hours per day) are noted. Despite a good appetite, there is a loss of body weight due to constant activity and movements, which requires high energy costs. Mental agitation is manifested by a reassessment of one’s abilities and role in society. As a result, the patient can impersonate a talented person in various fields (art, politics, business, etc.), to which he had not the slightest relationship before the illness.

In the phase of depression, the patient becomes lethargic, lethargic, with a depressed mood, lack of vital interest, deterioration of professional skills or even loss of capacity for work. Thinking processes become slow, reactions are inhibited, cognitive abilities decrease. Motor activity is significantly reduced, physical inactivity develops, more time is spent on the performance of previous tasks. Appetite disappears (leads to weight loss), drowsiness appears (especially in the daytime). A depressive episode is characterized by suspiciousness, constant anxiety, and indifference to surrounding events, including those that directly concern the patient himself. There are problems in the genital area (loss of libido, impotence in men, amenorrhea in women).

Sometimes, instead of an episode of mania in bipolar affective disorder, there may be an episode of hypomania, which manifests itself with the same symptoms, but with a moderate, less pronounced manifestation (increased mood, vigor, quick speech, moderately fast movements).

The course of manic-depressive psychosis can have various options. Mania episodes are slightly shorter than episodes of depression. On average, 1-2 months and 3-7 months, respectively, but the timing can vary from two weeks to two years. Variation is also observed in the alternation of mania and depression: they can replace each other without "bright" intervals, with the presence of a "bright gap" between each phase or between a pair of "mania-depression". Sometimes the alternation of mania and depression is random, or one of the phases may be completely absent (only episodes of mania or only episodes of depression). In the latter case, differential diagnosis with recurrent depression is significantly more difficult.

Treatment of Bipolar Affective Disorders

Therapy of bipolar affective disorders is a very difficult task. At Clinic K + 31, highly qualified specialists with extensive experience in psychiatry deal with the treatment of manic-depressive psychoses. Given the severity of this mental disorder, after a diagnosis is established, non-drug methods (psychotherapy) are immediately combined with the appointment of several groups of drugs (psychopharmacology).

The treatment of bipolar disorder should take into account the phase of the course of the disease (mania or depression), so patients are constantly monitored by a psychotherapist for timely adjustment of prescribed drugs. In the episode of depression, the key group is antidepressants, antipsychotics, lithium drugs and anticonvulsants remain in the background to prevent or ameliorate the episode of mania. When a manic episode returns, the treatment regimen changes with emphasis on normotics and antipsychotics.

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