Eosinophils are included in the list of indicators of the leukocyte formula, their rate is 1-5%. They play a major role in the neutralization and destruction of foreign cells circulating in the blood and in tissues (parasites, protists, bacteria). This happens by the development of special receptors that bind to immunoglobulin-E with the formation of a cytotoxic (cell-destroying) complex.
EO activation occurs both independently and after the absorption of mediators released by basophils. Due to the large accumulation of IgE in the area of concentration of eosinophils, an allergic reaction of the type of anaphylactic shock may develop.
EO activation occurs both independently and after the absorption of mediators released by basophils. Due to the large accumulation of IgE in the area of concentration of eosinophils, an allergic reaction of the type of anaphylactic shock may develop.
Considering the main functions of the EO, an increase in their number can be observed when:
Recovery after an infectious and inflammatory process is a favorable sign;
Parasitic invasion of the body;
Activation of various allergic reactions, including those occurring in a chronic form (bronchial asthma, dermatitis, hay fever);
Autoimmune systemic diseases;
Malignant lesions of the red bone marrow (leukemia), lymphoid tissue (lymphoma);
Metastatic tumors of internal organs (especially with metastases to the lungs, bones).
Eosinophils decrease in the case of:
The height of the infection;
Immunosuppression (cytostatics, glucocorticoid hormones);
The use of antiallergic drugs;
Bone marrow emptying;
Severe condition of the patient.
In the absence of any pathological symptoms leading to a change in the number of eosinophils in the general analysis, it is necessary to perform this study at least once a year for prophylactic purposes.
